Important information about Combivent^® (ipratropium bromide and albuterol sulfate) Inhalation Aerosol

COMBIVENT Inhalation Aerosol should not be used in patients who:

• Are allergic to soya lecithin or related food products such as soybeans and peanuts
• Are allergic to any of the ingredients in COMBIVENT Inhalation Aerosol or to atropine or other similar drugs

COMBIVENT Inhalation Aerosol can cause the narrowing of the airways to get worse (paradoxical bronchospasm) in some patients, which may be life threatening. Stop taking COMBIVENT Inhalation Aerosol and call your doctor or get emergency help if this happens.

COMBIVENT Inhalation Aerosol can cause serious heart-related side effects, such as an increase in pulse, blood pressure, and/or related symptoms.

Deaths have been reported with similar inhaled medicines in asthma patients who use the medicine too much. Do not use COMBIVENT Inhalation Aerosol more often than your healthcare provider has directed.

COMBIVENT Inhalation Aerosol can cause serious allergic reactions. Symptoms include itching, swelling of the face, lips, tongue, or throat (which may cause difficulty in breathing or swallowing), skin rash, hives, bronchospasm (airway narrowing), or anaphylaxis. Stop taking COMBIVENT Inhalation Aerosol and call your doctor or get emergency help if you get any of these symptoms.

Certain conditions may increase your risk of side effects with COMBIVENT Inhalation Aerosol.

Tell your healthcare provider about all of your conditions, including if you:

• Have narrow-angle glaucoma
• Have prostate or urinary problems
• Have a history of heart disease (e.g., reduced heart circulation, irregular heartbeat, and high blood pressure)
• Have seizures
• Have a thyroid disorder
• Have diabetes
• Have low potassium levels
• Have kidney disease
• Have liver disease
• Are pregnant, are trying to become pregnant, or are breast-feeding